Photo Product Price Buy
Angry Orange Pet...image Angry Orange Pet Odor Eliminator for Dog and Cat Urine, Makes 1 Gallon of Solution for Carpet, Furniture and Floor Stains $22.97
TriNova Natural Pet...image TriNova Natural Pet Stain and Odor Remover Eliminator - Advanced Enzyme Cleaner Spray - Remove Old & New Pet Stains & Smells for Dogs & Cats - All-Surface Safe - 32 OZ $15.97
Rocco & Roxie...image Rocco & Roxie Professional Strength Stain & Odor Eliminator - Enzyme-Powered Pet Odor & Stain Remover for Dog and Cats Urine - Carpet Cleaner Spray - Enzymatic Cat Pee Destroyer - for Small Animals $19.93 ($0.62 / Fl Oz)
Simple Solution Pet...image Simple Solution Pet Stain and Odor Remover | Enzymatic Cleaner with 2X Pro-Bacteria Cleaning Power | 32 Ounces $8.99 ($0.28 / Fluid Ounce)
Pet Stain &...image Pet Stain & Odor Miracle - The Best Enzyme Cleaner for Dog Urine Cat Pee Feces Vomit, Enzymatic Solution Cleans Carpet Rug Car Upholstery Couch Mattress Furniture, Natural Eliminator (S/M 32FL OZ) $19.97
Life Miracle Enzyme...image Life Miracle Enzyme Cleaner & Pet Odor Eliminator Concentrate | Deep Cleaning Enzymatic Spot Remover for Dog Cat Urine, Rug, Carpet, Upholstery, Couch & Car Stains & Smells | Makes 2 GALLONS $34.97
BUBBAS Super Strength...image BUBBAS Super Strength Commercial Enzyme Cleaner - Pet Odor Eliminator | Enzymatic Stain Remover | Remove Dog Cat Urine Smell from Carpet, Rug or Hardwood Floor and Other Surfaces (Gallon) $39.97 ($0.31 / Fl Oz)
Nature's Miracle Advance...image Nature's Miracle Advance Cat Stain and Odor Eliminator 32 oz $13.37 ($0.42 / Fl Oz)
NonScents Stain &...image NonScents Stain & Odor Eliminator - Fragrance Free - Pet Odor & Stain Remover for Dog and Cat Urine $14.94 ($0.12 / Fl Oz)

Having a pet, especially a cat, is never an easy task. Cats are very sensitive, and taking care of them requires a lot of patience, sympathy, and love – just like taking care of your child.

Your cat may be too weak so she can have a disease anytime you pay less attention to her, or sometimes she just disappears for a period – making you sad and cry a lot.

But there is one problem that every cat owner is getting: what is the best enzyme cleaner for cat urine?

Understanding your concerns and the with determination to help, we are here to share a list of 10 best enzyme cleaner for cat urine. Let’s check it out.

Enzyme Cleaner Overview

What Is An Enzyme Cleaner?

Enzyme cleaner, also known as an enzyme-based cleaner, is no longer a new name, although it has gained significant popularity and has been widely known by professionals.

Enzyme cleaners are primary products for washing that take advantage of good bacteria to digest soils, specks of dirt, debris, and dust. The enzymes contained in these cleaners are no longer alive, and you cannot see any growth or reproduction from them.

Which Enzymes Those Cleaners Contain?

There are three main enzymes in those enzyme cleaners, called amylases, lipase, proteases. Each one is used for a certain kind of breakdown. Amylases eliminate starch molecules, while fat molecules such as greases and oils are eliminated by lipase, and proteases are for the elimination of protein-based molecules such as food and blood.

What Are The Benefits Of Enzymes Cleaners?

Using enzymes cleaners brings about many benefits, such as:

  • Instead of negatively affecting human health and environment like medical products, enzymes cleaners are safe for both.
  • The micro-organisms in these enzymes cleaners show their crucial role in penetrating small crevices and taking part in the breakdown of malodors and soils that can never be removed by traditional chemicals.
  • Enzymes and bacteria can work continuously for more than 80 hours after the implementation thanks to the form of residuals, making sure to remove malodors and the soils altogether. 
  • Healthy non-pathogenic bacteria is another factor that makes enzyme cleaners useful. They can assist in displacing disease-causing bacteria, which improve the health of humans. 

The best enzyme cleaner for cat urine

Angry Orange is a business-grade citrus odor remover that was initially developed aiming at manufacturing apps such as barn lot, sludge ponds, poultry farms, washing machines, pet extraction businesses, and visiting kennels.

Meeting FDA-GRAS standards, you can be surprised by the biodegradable and non-toxic formula that can make use of the oil derived from orange peel.

You can see the impressive effect of this product while using it for removing odors in cat litter boxes or for the elimination of ammonia and methane ones. What’s more, pet odor is now the issue in many places such as on the carpet, tile, around the tree, bushes. 

This product also helps you to save money while you pay less than $7.5 for each 32oz of healthy cleaners instead of about $20 for a basic cleaner that even cannot works with pet odors.

One thing that can make you dislike this product is its smell. Some people think that it’s fine, while others think it smells noxious, which is ‘even worse than cat pee’ or ‘it smells like chemical plastic.’ This is depending on you.


  • Biodegradable and non-toxic formula with the oil derived from orange peel – safe for living beings health and environment-friendly.
  • Meet the FDA-GRAS standards.
  • Various uses for pet odor elimination in anywhere.
  • Saving money while purchasing a better product.


  • Some people may not like the smell of this product.

Every pet owner has some concerns about their pets’ health when using this kind of product as those companies usually use chemical ingredients. Those things can negatively affect even your health and environment apart from the pet’s health. 

Everything will change with TriNova Natural Pet Stain and Odor Remover Eliminator. The formula is made of 100% natural and organic ingredients, and all of them are listed on the label.

For this reason, you no longer have to worry about it even when you have kids or other pets. 

The blend of natural enzymes contained in this product shows its impressive strength by tackling stains and odors completely. After the breakdown, it dries out and disintegrates to turn your litter box to the like-new condition. 

What’s more, this product is spray – which is user-friendly as it does not need any additional steps like other enzyme cleaners. 

About the smell, many users said that it smells like perfume, and it’s horrible to them, while others find it no problem.


  • Made of 100% natural and organic ingredients that are listed on the label.
  • Safe for kids and other pets.
  • Impressive strength in removing odors at their root.
  • The spray makes it easier to use for the beginners – not any additional steps.


  • The smells maybe not in favor.

Another spray is on this list, and this also means that even when you are a beginner, there’s nothing to worry about how to use it.

The natural enzymatic bacteria in this cleaner is so strong. Thanks to the activation of the connection with odors and stains, it feeds on the ammonia crystals to remove them at their root. 

This product is safe for pets and kids – two of the subjects are most easily affected in a negative way. You can use Rocco & Roxie Professional Strength Stain & Odors Eliminator for cat urine without any hazardous propellants left behind. 

Carpet and Rug Institue (CRI) have given this product the Seal of Approval as a certification for safe insurance. 

It can be used anywhere you find odors and stains such as carpet, cat litter box, trees, yard, and even hardwood floor. 

In addition, this product pre-treat your laundry in the best way that you never think of. 

However, the enzyme cleaner may leave a ‘horrible smell’ after being used, according to some reviews. Be aware of it. 


  • User-friendly
  • Safe for pets and kids (earning the Seal of Approval by Carpet and Rug Institue)
  • Can be used anywhere you find odors and stains
  • Works great to pre-treat the laundry


  • May leave an uncomfortable smell after being used.

Do you wonder what makes this product different from the others? It is the unique Pro-bacteria that not only eliminates stains and odors but also helps prevent repeat marking.

This cleaner comes with multiple uses for safely removing odors and stains from carpet, cat litter box, floor, clothing, and so on. For this reason, it is a perfect choice for pre-treating your laundry. 

What’s more, this product comes with great versatility thanks to the 3-in-1 sprayer: stream, foam, and mist. And the affordable price helps low-budget pet owners solve their problems with pet stains.

One thing you need to consider is the design of that bottle. It makes the liquid easily leaks away through the neck even during the application. And it also cannot remove the smells of cat urine completely. 


  • The unique formula with Pro-bacteria 
  • Multiple uses 
  • Great versatility with a 3-in-1 sprayer: stream, foam, and mist
  • Affordable price for low-budget users


  • The design of the bottle makes liquid easily leaks away through the neck
  • Cannot remove the smells of cat urines completely

This product is a miracle, just like its name. With the multiple-surface feature, Pet Stain & Odor Miracle can be safely used to remove stains and odors on a lot of surfaces such as cat litter box, carpet, floor (including hardwood floor). 

The cleaner gains both the safety for children and pets and effectiveness thanks to its powerful natural enzymatic formula. 

A special feature of this enzyme cleaners is in the smells. This product smells very good (like honey and flower). Anything with bad smells can be solved by this miracle as quickly as possible. 

However, this is not suitable for dark color carpet since it will ruin the color and tell people to know that there has been cat urine on it before.


  • Multiple-surface cleaning
  • Good smells
  • Safe for children and pets thanks to the powerful natural enzymatic formula


  • Not work much on dark color carpet

The first factor people care about when they are deciding to choose any cleaner is whether it is safe or not. Many health problems come from household chemicals, and of course, you don’t want to see that result. So here is what you need.

Life Miracle Enzyme Cleaner is an amazing product with natural formula, promising that there won’t be any problems. 

Apart from an eco-friendly product, this cleaner does this work very well as a non-toxic and allergy-free remover. 

The cleaner also comes with great versatility while it is used effectively on any surface: cat litter box, floor, carpet, and so on.

And the same as some products above, the cleaner makes its users very uncomfortable due to the bad smell. Be aware of it.


  • Non-toxic, eco-friendly, allergy-free, and safe for human health
  • Great versatility when using on any surfaces


  • Bad smell

The price is not very affordable, right? So what we get after paying more than $30 for this gallon of cleaner? It’s the scientific formula that is more potent than any other product and, at the same time, still safe for pets. Instead of completely remove stains and odors, the cleaner shows its strength by the permanent breakdown of pet stains, thus preventing repeat marking.

Using BUBBAS Super Strength Commercial Enzyme Cleaner, we can solve nearly all the problems with stains, on anywhere: carpet, floor, clothes, and so on.

But this product has a warning from the company: the choking hazard – not for children under 3 years. So if you have small kids, this is not for you. And the smell is not very good, as well.


  • One of the most potent enzyme cleaner and still safe for pets
  • It can be used anywhere we find stains and odors: carpet, floor, so on.


  • The price is quite high
  • Not safe for under-three children
  • Bad smells

Sometimes, some cat messes are too severe, and normal cleaner cannot completely solve. This is what this powerful enzymatic formula does for you. Tough stains and odors from cat urine are not a problem with it, and everything will be done in 15 minutes.

This is specialized products for tough surfaces such as carpet, tile, and linoleum, so you don’t have to concern about its effectiveness.

Another question: What should I do if I am sensitive to fragrance? Don’t purchase this product! The strong formula poses a significant threat to your health, and the smells from this are not comfortable – be careful as it may be toxic.


  • One of the strongest formula that works well on tough surfaces such as carpet, tile, and linoleum.
  • Super effective
  • Time-saving: with just 15 minutes


  • Maybe hazardous for people who are sensitive to fragrance
  • Smells too chemically

According to the company, this is good news with people sensitive to fragrance as NonScents Stain & Odor Eliminator is fragrance-free. It works very well in eliminating stains and odors without artificial fragrance covering the stains.

Great versatility is another pro of using this NonScents product. Carpet, floor, yard, clothes, etc. – are all places for this eliminator. 

However, the strong formula makes it smell very bad and not very safe for kids. And even for adults, it can cause itchiness. So always keep this away from under three kids.


  • Fragrance-free
  • Great versatility


  • The formula is too strong
  • Bad smells
  • Not safe for under three kids and can cause itchiness for adults.

The Bottom Lines

This list of the best cleaners for cat urine is our final result after researching and launching surveys, so we believe that they are the right choice for you, whatever is your demand. Some additional information we give you will be useful for you to make the decision. I hope that you would always feel comfortable with those products.


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